Isaac Guerendo 
RB • San Francisco 49ers
AGE: 25 (06/28/2000)
STATUS: QUESTIONABLE (Shoulder)
Pros & Cons for 2025
Projections for 2025
Stats This Year (2025)
CLOSEST COMP: (comparisons start in Week 3)
| Week 1 | |
| @ SEA | |
| TBD | |
Matchup Rating:  |
| Week 2 | |
| @ NO | |
| TBD | |
Matchup Rating: |
| Week 3 | |
| vs. ARZ | |
| TBD | |
Matchup Rating: |
| Week 4 | |
| vs. JAX | |
| TBD | |
Matchup Rating: |
| Week 5 | |
| @ LAR | |
| TBD | |
Matchup Rating: |
| Week 6 | |
| @ TB | |
| TBD | |
Matchup Rating: |
| Week 7 | |
| vs. ATL | |
| TBD | |
Matchup Rating: |
| Week 8 | |
| @ HOU | |
| TBD | |
Matchup Rating: |
| Week 9 | |
| @ NYG | |
| TBD | |
Matchup Rating: |
| Week 10 | |
| vs. LAR | |
| TBD | |
Matchup Rating: |
| Week 11 | |
| @ ARZ | |
| TBD | |
Matchup Rating: |
| Week 12 | |
| vs. CAR | |
| TBD | |
Matchup Rating: |
| Week 13 | |
| @ CLE | |
| TBD | |
Matchup Rating: |
| Week 14 | |
| BYE |
| Week 15 | |
| vs. TEN | |
| TBD | |
Matchup Rating: |
| Week 16 | |
| @ IND | |
| TBD | |
Matchup Rating: |
| Week 17 | |
| vs. CHI | |
| TBD | |
Matchup Rating: |
| Week 18 | |
| vs. SEA | |
| TBD | |
Matchup Rating: |
| Season Totals | |
| STD: | 0 |
| PPR: | 0 |
| Carr: | |
| Yds: | |
| TD: | |
| Rec: | |
| Targ: | |
| Yds: | |
| TD: | |
| Week 1 | |
| vs. NYJ | |
| DNP |
| Week 2 | |
| @ MIN | |
| STD: | 0 |
| PPR: | 0 |
| Carr: | 1 |
| Yds: | 0 |
| TD: | 0 |
| Rec: | 0 |
| Targ: | 0 |
| Yds: | 0 |
| TD: | 0 |
| Week 3 | |
| @ LAR | |
| STD: | 1.9 |
| PPR: | 1.9 |
| Carr: | 5 |
| Yds: | 19 |
| TD: | 0 |
| Rec: | 0 |
| Targ: | 0 |
| Yds: | 0 |
| TD: | 0 |
| Week 4 | |
| vs. NE | |
| STD: | 0 |
| PPR: | 0 |
| Carr: | 1 |
| Yds: | 0 |
| TD: | 0 |
| Rec: | 0 |
| Targ: | 0 |
| Yds: | 0 |
| TD: | 0 |
| Week 5 | |
| vs. ARZ | |
| STD: | 2.2 |
| PPR: | 2.2 |
| Carr: | 5 |
| Yds: | 22 |
| TD: | 0 |
| Rec: | 0 |
| Targ: | 0 |
| Yds: | 0 |
| TD: | 0 |
| Week 6 | |
| @ SEA | |
| STD: | 9.9 |
| PPR: | 9.9 |
| Carr: | 10 |
| Yds: | 99 |
| TD: | 0 |
| Rec: | 0 |
| Targ: | 0 |
| Yds: | 0 |
| TD: | 0 |
| Week 7 | |
| vs. KC | |
| STD: | 0.7 |
| PPR: | 1.7 |
| Carr: | 1 |
| Yds: | 2 |
| TD: | 0 |
| Rec: | 1 |
| Targ: | 1 |
| Yds: | 5 |
| TD: | 0 |
| Week 8 | |
| vs. DAL | |
| STD: | 16.2 |
| PPR: | 19.2 |
| Carr: | 14 |
| Yds: | 85 |
| TD: | 1 |
| Rec: | 3 |
| Targ: | 4 |
| Yds: | 17 |
| TD: | 0 |
| Week 9 | |
| BYE |
| Week 10 | |
| @ TB | |
| STD: | 0 |
| PPR: | 0 |
| Carr: | 1 |
| Yds: | 0 |
| TD: | 0 |
| Rec: | 0 |
| Targ: | 0 |
| Yds: | 0 |
| TD: | 0 |
| Week 11 | |
| vs. SEA | |
| DNP |
| Week 12 | |
| @ GB | |
| DNP |
| Week 13 | |
| @ BUF | |
| STD: | 7.6 |
| PPR: | 8.6 |
| Carr: | 4 |
| Yds: | 19 |
| TD: | 1 |
| Rec: | 1 |
| Targ: | 1 |
| Yds: | -3 |
| TD: | 0 |
| Week 14 | |
| vs. CHI | |
| STD: | 24.8 |
| PPR: | 26.8 |
| Carr: | 15 |
| Yds: | 78 |
| TD: | 2 |
| Rec: | 2 |
| Targ: | 2 |
| Yds: | 50 |
| TD: | 0 |
| Week 15 | |
| vs. LAR | |
| STD: | 7.5 |
| PPR: | 11.5 |
| Carr: | 16 |
| Yds: | 57 |
| TD: | 0 |
| Rec: | 4 |
| Targ: | 4 |
| Yds: | 18 |
| TD: | 0 |
| Week 16 | |
| @ MIA | |
| DNP |
| Week 17 | |
| vs. DET | |
| STD: | 9.9 |
| PPR: | 13.9 |
| Carr: | 9 |
| Yds: | 34 |
| TD: | 0 |
| Rec: | 4 |
| Targ: | 4 |
| Yds: | 65 |
| TD: | 0 |
| Week 18 | |
| @ ARZ | |
| STD: | 0.5 |
| PPR: | 0.5 |
| Carr: | 2 |
| Yds: | 5 |
| TD: | 0 |
| Rec: | 0 |
| Targ: | 0 |
| Yds: | 0 |
| TD: | 0 |
| Season Totals | |
| STD: | 81.2 |
| PPR: | 96.2 |
| Carr: | 84 |
| Yds: | 420 |
| TD: | 4 |
| Rec: | 15 |
| Targ: | 16 |
| Yds: | 152 |
| TD: | 0 |
